Resistance to Noise-Induced Hearing Loss in 129S6 and MOLF Mice: Identification of Independent, Overlapping, and Interacting Chromosomal Regions
Identifieur interne : 000114 ( Main/Exploration ); précédent : 000113; suivant : 000115Resistance to Noise-Induced Hearing Loss in 129S6 and MOLF Mice: Identification of Independent, Overlapping, and Interacting Chromosomal Regions
Auteurs : Valerie A. Street [États-Unis] ; Sharon G. Kujawa [États-Unis] ; Ani Manichaikul [États-Unis] ; Karl W. Broman [États-Unis] ; Jeremy C. Kallman [États-Unis] ; Dustin J. Shilling [États-Unis] ; Ayaka J. Iwata [États-Unis] ; Linda C. Robinson [États-Unis] ; Carol A. Robbins [États-Unis] ; Jin Li [États-Unis] ; M. Charles Liberman [États-Unis] ; Bruce L. Tempel [États-Unis]Source :
- JARO: Journal of the Association for Research in Otolaryngology [ 1525-3961 ] ; 2014.
Abstract
Noise-induced hearing loss (NIHL) is a prevalent health risk. Inbred mouse strains 129S6/SvEvTac (129S6) and MOLF/EiJ (MOLF) show strong NIHL resistance (NR) relative to CBA/CaJ (CBACa). In this study, we developed quantitative trait locus (QTL) maps for NR. We generated F1 animals by intercrossing (129S6 × CBACa) and (MOLF × CBACa). In each intercross, NR was recessive. N2 animals were produced by backcrossing F1s to their respective parental strain. The 232 N2-129S6 and 225 N2-MOLF progenies were evaluated for NR using auditory brainstem response. In 129S6, five QTL were identified on chromosomes (Chr) 17, 18, 14, 11, and 4, referred to as loci
Url:
DOI: 10.1007/s10162-014-0472-x
PubMed: 24952082
PubMed Central: 4164691
Affiliations:
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Street</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Kujawa, Sharon G" sort="Kujawa, Sharon G" uniqKey="Kujawa S" first="Sharon G." last="Kujawa">Sharon G. Kujawa</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Otology and Laryngology, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA 22908 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Broman, Karl W" sort="Broman, Karl W" uniqKey="Broman K" first="Karl W." last="Broman">Karl W. Broman</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Kallman, Jeremy C" sort="Kallman, Jeremy C" uniqKey="Kallman J" first="Jeremy C." last="Kallman">Jeremy C. Kallman</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Shilling, Dustin J" sort="Shilling, Dustin J" uniqKey="Shilling D" first="Dustin J." last="Shilling">Dustin J. Shilling</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7">Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Iwata, Ayaka J" sort="Iwata, Ayaka J" uniqKey="Iwata A" first="Ayaka J." last="Iwata">Ayaka J. Iwata</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7">Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Robinson, Linda C" sort="Robinson, Linda C" uniqKey="Robinson L" first="Linda C." last="Robinson">Linda C. Robinson</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Robbins, Carol A" sort="Robbins, Carol A" uniqKey="Robbins C" first="Carol A." last="Robbins">Carol A. Robbins</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Li, Jin" sort="Li, Jin" uniqKey="Li J" first="Jin" last="Li">Jin Li</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Liberman, M Charles" sort="Liberman, M Charles" uniqKey="Liberman M" first="M. Charles" last="Liberman">M. Charles Liberman</name><affiliation wicri:level="2"><nlm:aff id="Aff3">The Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Otology and Laryngology, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Tempel, Bruce L" sort="Tempel, Bruce L" uniqKey="Tempel B" first="Bruce L" last="Tempel">Bruce L. Tempel</name><affiliation wicri:level="2"><nlm:aff id="Aff1">The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>The V.M. Bloedel Hearing Research Center, Department of Otolaryngology–HNS, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Pharmacology, University of Washington, Seattle, WA 98195 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Pharmacology, University of Washington, Seattle</wicri:cityArea></affiliation></author></analytic><series><title level="j">JARO: Journal of the Association for Research in Otolaryngology</title><idno type="ISSN">1525-3961</idno><idno type="e-ISSN">1438-7573</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Noise-induced hearing loss (NIHL) is a prevalent health risk. Inbred mouse strains 129S6/SvEvTac (129S6) and MOLF/EiJ (MOLF) show strong NIHL resistance (NR) relative to CBA/CaJ (CBACa). In this study, we developed quantitative trait locus (QTL) maps for NR. We generated F1 animals by intercrossing (129S6 × CBACa) and (MOLF × CBACa). In each intercross, NR was recessive. N2 animals were produced by backcrossing F1s to their respective parental strain. The 232 N2-129S6 and 225 N2-MOLF progenies were evaluated for NR using auditory brainstem response. In 129S6, five QTL were identified on chromosomes (Chr) 17, 18, 14, 11, and 4, referred to as loci <italic>nr1</italic>, <italic>nr2</italic>, <italic>nr3</italic>, <italic>nr4</italic>, and <italic>nr5</italic>, respectively. In MOLF, four QTL were found on Chr 4, 17, 6, and 12, referred to as <italic>nr7</italic>, <italic>nr8</italic>, <italic>nr9</italic>, and <italic>nr10</italic>, respectively. Given that NR QTL were discovered on Chr 4 and 17 in both the N2-129S6 and N2-MOLF cross, we generated two consomic strains by separately transferring 129S6-derived Chr 4 and 17 into an otherwise CBACa background and a double-consomic strain by crossing the two strains. Phenotypic analysis of the consomic strains indicated that whole 129S6 Chr 4 contributes strongly to mid-frequency NR, while whole 129S6 Chr 17 contributes markedly to high-frequency NR. Therefore, we anticipated that the double-consomic strain containing Chr 4 and 17 would demonstrate NR across the mid- and high-frequency range. However, whole 129S6 Chr 17 masks the expression of mid-frequency NR from whole 129S6 Chr 4. To further dissect NR on 129S6 Chr 4 and 17, CBACa.129S6 congenic strains were generated for each chromosome. Phenotypic analysis of the Chr 17 CBACa.129S6 congenic strains further defined the NR region on proximal Chr 17, uncovered another NR locus (<italic>nr6</italic>) on distal Chr 17, and revealed an epistatic interaction between proximal and distal 129S6 Chr 17.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Pennsylvanie</li><li>Virginie</li><li>Washington (État)</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Street, Valerie A" sort="Street, Valerie A" uniqKey="Street V" first="Valerie A." last="Street">Valerie A. Street</name></region><name sortKey="Broman, Karl W" sort="Broman, Karl W" uniqKey="Broman K" first="Karl W." last="Broman">Karl W. Broman</name><name sortKey="Iwata, Ayaka J" sort="Iwata, Ayaka J" uniqKey="Iwata A" first="Ayaka J." last="Iwata">Ayaka J. Iwata</name><name sortKey="Iwata, Ayaka J" sort="Iwata, Ayaka J" uniqKey="Iwata A" first="Ayaka J." last="Iwata">Ayaka J. Iwata</name><name sortKey="Kallman, Jeremy C" sort="Kallman, Jeremy C" uniqKey="Kallman J" first="Jeremy C." last="Kallman">Jeremy C. Kallman</name><name sortKey="Kujawa, Sharon G" sort="Kujawa, Sharon G" uniqKey="Kujawa S" first="Sharon G." last="Kujawa">Sharon G. Kujawa</name><name sortKey="Li, Jin" sort="Li, Jin" uniqKey="Li J" first="Jin" last="Li">Jin Li</name><name sortKey="Liberman, M Charles" sort="Liberman, M Charles" uniqKey="Liberman M" first="M. Charles" last="Liberman">M. Charles Liberman</name><name sortKey="Liberman, M Charles" sort="Liberman, M Charles" uniqKey="Liberman M" first="M. Charles" last="Liberman">M. Charles Liberman</name><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><name sortKey="Robbins, Carol A" sort="Robbins, Carol A" uniqKey="Robbins C" first="Carol A." last="Robbins">Carol A. Robbins</name><name sortKey="Robinson, Linda C" sort="Robinson, Linda C" uniqKey="Robinson L" first="Linda C." last="Robinson">Linda C. Robinson</name><name sortKey="Shilling, Dustin J" sort="Shilling, Dustin J" uniqKey="Shilling D" first="Dustin J." last="Shilling">Dustin J. Shilling</name><name sortKey="Shilling, Dustin J" sort="Shilling, Dustin J" uniqKey="Shilling D" first="Dustin J." last="Shilling">Dustin J. Shilling</name><name sortKey="Tempel, Bruce L" sort="Tempel, Bruce L" uniqKey="Tempel B" first="Bruce L" last="Tempel">Bruce L. Tempel</name><name sortKey="Tempel, Bruce L" sort="Tempel, Bruce L" uniqKey="Tempel B" first="Bruce L" last="Tempel">Bruce L. 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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24952082" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MozartV1
| This area was generated with Dilib version V0.6.20. |  |